00406nas a2200121   4500000000100000000000100001008004100002260002100043100002200064700002700086700001800113245015300131       2021                            d  c15 November 20211 aJhonattan Miranda1 aMaria Ramírez-Montoya1 aArturo Molina00aEducation 4.0 Reference Framework for the Design of Teaching-Learning Systems: Two Case Studies Involving Collaborative Networks and Open Innovation