The article examines uranium ore manifestations, mining and associated radon emanation potential from the point of view of radiation hazard to the environment in the region of the Ukrainian Shield and its slopes, namely within the Central Ukrainian Uranium Province. The maximum amount of radon is established in the geodynamically active zones in overlapping rocks associated with new tectonic anomalies in parent rocks. Most hazardous are areas where new tectonic activation zones and uranium ore manifestations occur relatively close to the surface. The approach towards ‘radon-prone areas’ in accordance with the European Basic Safety Standards is emphasized.